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18 de marzo. Conferencia de la Dra. Eliane Piaggio

Publicado el 15/03/2011 en Facultad de Ciencias Qu铆micas

Dra. Eliane Paggio
I3: Immunology-Immunopathology-Immunotherapy
UMR 7211 (UPMC/CNRS), U 959 (INSERM)
Bâtiment CERVI, CHU Pitié-Salpêtrière
75651 Paris Cedex 13 (France)

Título
Regulatory T cell biology and therapeutic application.

Resumen
Regulatory T cells (Tregs) play a major role in regulating the immune response. We have studied the impact of Treg stimulation in mouse models of type 1 diabetes (T1D). We have described that activated conventional T cells boost Treg expansion and function, by a mechanism partially mediated by TNF-a (Grinberg-Bleyer et al, JCI 2010). Also, we have shown that another way to boost Tregs is low-dose IL-2 administration. Indeed, 5 days of low-dose IL-2 administration can reverse new onset diabetes in non obese diabetic mice (NOD) by locally acting on pancreas infiltrating Tregs (Grinberg-Bleyer et al, JEM 2010). Consequently, we have now proposed a clinical trial in recent onset diabetic patients.

Lugar
Sala de Conferencias. 1er piso Edificio Integrador. Facultad de Ciencias Químicas. UNC. Ciudad Universitaria.

Fecha
Viernes 18 de Marzo. 12 hs.

Organizan
UCC y UNC

Comunidad UCC

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